Discussion:
comparision of hydrophobicity
(too old to reply)
Liwen
2011-01-12 23:12:50 UTC
Permalink
I am having a difficulty comparing the hydrophobicity of some organic
compounds. Is there any database that can help?
1:2-amino-3-mercaptopropanoic acid
2:2-amino-3-sulfinopropanoic acid
3:2-amino-3-sulfinamoylpropanoic acid
4:2-amino-3-hydrosulfonylpropanoic acid
5:2-amino-3-((2-amino-2-oxoethyl)thio)propanoic acid
6:2-amino-3-((1-ethyl-2,5-dioxopyrrolidin-3-yl)thio)propanoic acid

These are the 6 compunds. Their structures cannot be posted in this
message so I use ChemBio Draw to convert the structures to names.

If someone can point out the order of their hydrophobicity/polarity,
that would be very helpful.
Thanks.
Theodore Heise
2011-01-15 17:41:48 UTC
Permalink
On Wed, 12 Jan 2011 15:12:50 -0800 (PST),
Post by Liwen
I am having a difficulty comparing the hydrophobicity of some organic
compounds. Is there any database that can help?
1?2-amino-3-mercaptopropanoic acid
2?2-amino-3-sulfinopropanoic acid
3?2-amino-3-sulfinamoylpropanoic acid
4?2-amino-3-hydrosulfonylpropanoic acid
5?2-amino-3-((2-amino-2-oxoethyl)thio)propanoic acid
6?2-amino-3-((1-ethyl-2,5-dioxopyrrolidin-3-yl)thio)propanoic acid
These are the 6 compunds. Their structures cannot be posted in this
message so I use ChemBio Draw to convert the structures to names.
If someone can point out the order of their hydrophobicity/polarity,
that would be very helpful.
Thanks.
It's been a long time since organic classes, but I wonder if this
is governed principally by the acid dissociation constants of the
propanoic acid function. If that's the case, the differences in
electron withdrawing power of the other moeities might be the key
to the answer.
--
Theodore (Ted) Heise <***@heise.nu> Bloomington, IN, USA
Loading...